Abstract Search

ea0011p336 | Diabetes, metabolism and cardiovascular | ECE2006

Relationship between testosterone and in vivo expression of adipoR1 in skeletal muscle in middle aged Caucasian men

Abstract withdrawn...

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ea0012oc19 | Pituitary, ovary and steroids | SFE2006

Metformin stimulates AMP kinase activity and increases lactate production in human granulosa cells

Richardson MC , Sreekumar R , Sellahewa L , Ingamells S , Cameron IT , Byrne CD

Insulin-stimulated lactate production by granulosa cells (GC) appears to be compromised in polycystic ovary syndrome (PCOS), and this may have an adverse effect on the provision of 3-C units essential for oocyte development. The insulin-sensitiser, metformin, has been used successfully as an adjunct to gonadotrophin therapy in PCOS. Our objective was to establish whether metformin increased AMP kinase (AMPK) activity and lactate production in human GC.GC...

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ea0011p335 | Diabetes, metabolism and cardiovascular | ECE2006

Relationships between plasma adiponectin and testosterone concentrations in middle-aged men and women

Zhang J , Holt RIG , Wild SH , Holt H , Poole RB , Zeng QX , Byrne CD

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ea0008p74 | Reproduction | SFE2004

Effect of gonadotrophin and insulin on the balance of sterol regulatory element-binding protein(SREBP) isoforms in human granulosa cells

Richardson MC , Cameron IT , Simonis CD , Das MC , Hodge TE , Zhang J , Byrne CD

Clinical insulin resistance, concomitant with higher circulating insulin, is implicated in the pathogenesis of polycystic ovary syndrome (PCOS) in which there is abnormal lipid metabolism with changes in ovarian hormone production. SREBPs are key transcriptional regulators of lipid biosynthesis and therefore may be involved in changes occurring in PCOS. We have examined whether insulin and gonadotrophin regulate SREBPs.Local ethical approval was granted ...

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Endocrine Abstracts

Relationship between testosterone and in vivo expression of adipoR1 in skeletal muscle in middle aged Caucasian men

Metformin stimulates AMP kinase activity and increases lactate production in human granulosa cells

Relationships between plasma adiponectin and testosterone concentrations in middle-aged men and women

Effect of gonadotrophin and insulin on the balance of sterol regulatory element-binding protein(SREBP) isoforms in human granulosa cells

BiosciAbstracts